Principal Clin Research Coord
Job Description
Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today.
The System Clinical Trial Office (SCTO) supports COH investigators in managing human-subjects research by coordinating multi-phase clinical studies under the direction of SCTO leadership, Disease/Modality Team Chairs, and Study Investigators. Principal Clinical Research Coordinators/Clinical Trial Portfolio Leads (CTPLs) serve as leads within their disease teams, mentoring staff, providing guidance to Clinical Trial Data Coordinators, and acting as subject matter experts while ensuring strict compliance with research protocols, GCP, FDA, NIH, HIPAA, and institutional policies. CTPLs manage complex portfolios of approximately 30–50 oncology trials, oversee administrative and operational execution, support regulatory compliance and patient safety, and ensure studies meet quality, timeline, and resource expectations. They collaborate closely with managers, disease team leadership, and coordinators, maintain effective communication across teams, and function as Lead Central Coordinators and primary contacts for sponsors, investigators, national clinical trials, Hope Pathways, portfolio updates, and study-related inquiries.
As a successful candidate, you will:
- Serves as the primary point of contact and liaison between study sponsors, investigators, and research teams, including managing Hope Pathways inquiries, eligibility criteria, and National Trial coordination.
- Oversees operational execution of studies, including patient registration, randomization, slot management, and study close-out activities, while supporting protocol implementation and troubleshooting issues.
- Ensures regulatory compliance and accurate documentation across systems (Florence, OnCore, iRIS, sponsor portals), including eRegulatory binders, study status updates, and required filings.
- Manages safety and sponsor reporting requirements, including AE/SAE collection, submission, and resolution of protocol deviations or unanticipated problems.
- Coordinates and participates in monitoring visits, audits, and inspections; addresses findings, communicates deadlines, prioritizes work, and contributes to process improvement initiatives.
Your qualifications should include:
Minimum Education:•Bachelor’s degree in science, Health or related field from an accredited university
Minimum Experience:•Minimum of 5-7 years research or relevant experience
•Experience with CTMS, EMR and eRegulatory Systems
•Working knowledge of clinical trials, Federal, State, and Local regulations, and FDA/IRB regulations and requirements
Required Courses/Training:
Req. Certification/Licensure:•Good Clinical Practice (GCP) within 1 month of employment
•Human Subjects Protection (HSP) within 1 month of employment
•SOCRA or ACRP Certification within two years of employment
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
To learn more about our Comprehensive Benefits, please CLICK HERE.
Salary / Pay Rate Information:
Pay Rate: $44.90 - $69.60 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
